Chemical synthesis of a pore-forming antimicrobial protein, caenopore-5, by using native chemical ligation at a Glu-Cys site

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Title

Chemical synthesis of a pore-forming antimicrobial protein, caenopore-5, by using native chemical ligation at a Glu-Cys site

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The University of Auckland Library

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ResearchSpace@Auckland

Description

The 2014 report from the World Health Organization (WHO) on antimicrobial resistance revealed an alarming rise in antibiotic resistance all around the world. Unlike classical antibiotics, with the exception of a few species, no acquired resistance towards antimicrobial peptides (AMPs) has been reported. Therefore, AMPs represent leads for the development of novel antibiotics. Caenopore-5 is constitutively expressed in the intestine of the nematode Caenorhabditis elegans and is a pore-forming ...

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Format

Research paper

Research format

Journal article

Date created

2015-01-19

Creator

Medini, Karima / Harris, Paul / Hards, K / Dingley, Andrew / Cook, GM / Brimble, Margaret

URL

http://hdl.handle.net/2292/27380

Related subjects

Cell Membrane / Animals / Caenorhabditis elegans / Caenorhabditis elegans Proteins / Recombinant Proteins / Anti-Infective Agents / Circular Dichroism / Magnetic Resonance Spectroscopy / Amino Acid Sequence / Protein Structure, Secondary / Protein Folding / Permeability / Molecular Sequence Data / Chemistry Techniques, Synthetic / Solid-Phase Synthesis Techniques

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Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1439-4227/ http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1439-7633/homepage/2268_guidel.html

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• Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1439-4227/ http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1439-7633/homepage/2268_guidel.html
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