Effectiveness of fixed dose combination medication ('polypills') compared with usual care in patients with cardiovascular disease or at high risk: A prospective, individual patient data meta-analysis of 3140 patients in six countries

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Title

Effectiveness of fixed dose combination medication ('polypills') compared with usual care in patients with cardiovascular disease or at high risk: A prospective, individual patient data meta-analysis of 3140 patients in six countries

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Aims: To conduct a prospective, individual participant data (IPD) meta-analysis of randomised controlled trials comparing a polypill-based approach with usual care in high risk individuals. Methods and results: Three trials comparing polypill-based care with usual care in individuals with CVD or high calculated cardiovascular risk contributed IPD. Primary outcomes were self-reported adherence to combination therapy (anti-platelet, statin and ≥two blood pressure (BP) lowering agents), and diff...

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Format

Research paper

Research format

Journal article

Date created

2016-02-15

Creator

Webster, R / Patel, A / Selak, Vanessa / Billot, L / Bots, ML / Brown, A / Bullen, Christopher / Cass, A / Crengle, S / Elley, Carolyn / Grobbee, DE / Neal, B / Peiris, D / Poulter, N / Prabhakaran, D / Rafter, N / Stanton, A / Stepien, S / Thom, S / Usherwood, T / Wadham, A / Rodgers, A / SPACE Collaboration

URL

http://hdl.handle.net/2292/28179

Related subjects

Meta-analysis / Polypill / Secondary prevention / Cardiovascular disease

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