Chemically induced DNA hemimethylation and active demethylation

About this item

Title

Chemically induced DNA hemimethylation and active demethylation

Content partner

University of Otago

Collection

Otago University Research Archive

Description

The inheritance of epigenetic signals involves DNA methylation. DNA methylation patterns are inherited through cell generations by the action of DNA methyltransferases (DNMTs). During DNA replication DNMTs recognise hemimethylated DNA and, by the addition of methyl groups to the newly synthesised DNA, maintain methylation. However, the explanation of the cellular methylation machinery is far from completion and the current model of DNA methylation is controversial. Answering the question of h...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Doctoral

Date created

2016

Creator

Magrath, Helena

URL

https://hdl.handle.net/10523/6360

Related subjects

epigenetics

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