The Effect of Paracetamol on Core Body Temperature in Acute Traumatic Brain Injury: A Randomised, Controlled Clinical Trial.

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Title

The Effect of Paracetamol on Core Body Temperature in Acute Traumatic Brain Injury: A Randomised, Controlled Clinical Trial.

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Directory of Open Access Journals

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Directory of Open Access Journals

Description

Strategies to prevent pyrexia in patients with acute neurological injury may reduce secondary neuronal damage. The aim of this study was to determine the safety and efficacy of the routine administration of 6 grams/day of intravenous paracetamol in reducing body temperature following severe traumatic brain injury, compared to placebo.A multicentre, randomised, blind, placebo-controlled clinical trial in adult patients with traumatic brain injury (TBI). Patients were randomised to receive an i...

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Format

Research paper

Creator

Manoj K Saxena / Colman Taylor / Laurent Billot / Severine Bompoint / John Gowardman / Jason A Roberts / Jeffery Lipman / John Myburgh

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PLoS ONE

URL

http://europepmc.org/articles/PMC4683067?pdf=render

Related subjects

Medicine / Science

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