In Vitro and In Vivo Evaluation of Vancomycin-Loaded PMMA Cement in Combination with Ultrasound and Microbubbles-Mediated Ultrasound

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Title

In Vitro and In Vivo Evaluation of Vancomycin-Loaded PMMA Cement in Combination with Ultrasound and Microbubbles-Mediated Ultrasound

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Description

Ultrasound (US) has been used to increase elution of antibiotic from an antibiotic-loaded poly(methyl methacrylate) (PMMA) bone cement (ALBC). We aimed to further investigate whether microbubbles-mediated US (US + MB) facilitate elution of vancomycin (VAN) from cylindrical specimens and enhance the activity of the eluted antibiotic against Staphylococcus aureus (S. aureus) in vitro. The study groups comprised cylindrical bone cement fabricated with VAN (VAN), ALBC using US (VAN + US), and ALB...

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Format

Research paper

Date created

2015-01-01

Creator

Tiao Lin / Xun-Zi Cai / Ming-Min Shi / Zhi-Min Ying / Bin Hu / Chen-He Zhou / Wei Wang / Zhong-Li Shi / Shi-Gui Yan

Contributing partner

BioMed Research International

URL

http://dx.doi.org/10.1155/2015/309739

Related subjects

Medicine

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