Artemisinin-naphthoquine versus artemether-lumefantrine for uncomplicated malaria in Papua New Guinean children: an open-label randomized trial.

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Title

Artemisinin-naphthoquine versus artemether-lumefantrine for uncomplicated malaria in Papua New Guinean children: an open-label randomized trial.

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Directory of Open Access Journals

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Directory of Open Access Journals

Description

BACKGROUND: Artemisinin combination therapies (ACTs) with broad efficacy are needed where multiple Plasmodium species are transmitted, especially in children, who bear the brunt of infection in endemic areas. In Papua New Guinea (PNG), artemether-lumefantrine is the first-line treatment for uncomplicated malaria, but it has limited efficacy against P. vivax. Artemisinin-naphthoquine should have greater activity in vivax malaria because the elimination of naphthoquine is slower than that of lu...

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Format

Research paper

Date created

2014-12-01

Creator

Moses Laman / Brioni R Moore / John M Benjamin / Gumul Yadi / Cathy Bona / Jonathan Warrel / Johanna H Kattenberg / Tamarah Koleala / Laurens Manning / Bernadine Kasian / Leanne J Robinson / Naomi Sambale / Lina Lorry / Stephan Karl / Wendy A Davis / Anna Rosanas-Urgell / Ivo Mueller / Peter M Siba / Inoni Betuela / Timothy M E Davis

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PLoS Medicine

URL

http://europepmc.org/articles/PMC4280121?pdf=render

Related subjects

Medicine

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