Insulin versus Lipid Emulsion in a Rabbit Model of Severe Propranolol Toxicity: A Pilot Study

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Title

Insulin versus Lipid Emulsion in a Rabbit Model of Severe Propranolol Toxicity: A Pilot Study

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Directory of Open Access Journals

Description

Background and objective. Beta-blocker overdose may result in intractable cardiovascular collapse despite conventional antidotal treatments. High dose insulin/glucose (ING), and more recently intravenous lipid emulsion (ILE), have been proposed as potentially beneficial therapies in beta blocker intoxication. We compare efficacy of the novel antidotes ING, with ILE, in a rabbit model of combined enteric/intravenous propranolol toxicity. Methods. Sedated, mechanically ventilated and invasively...

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Format

Research paper

Date created

2011-01-01

Creator

Martyn Harvey / Grant Cave / Daniel Lahner / Jan Desmet / Gaynor Prince / Gary Hopgood

Contributing partner

Critical Care Research and Practice

URL

http://dx.doi.org/10.1155/2011/361737

Related subjects

Medical emergencies / Critical care / Intensive care / First aid

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