Long chain polyunsaturated fatty acids alter membrane-bound RANK-L expression and osteoprotegerin secretion by MC3T3-E1 osteoblast-like cells

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Title

Long chain polyunsaturated fatty acids alter membrane-bound RANK-L expression and osteoprotegerin secretion by MC3T3-E1 osteoblast-like cells

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Inflammation triggers an increase in osteoclast (bone resorbing cell) number and activity. Osteoclastogenesis is largely controlled by a triad of proteins consisting of a receptor (RANK), a ligand (RANK-L) and a decoy receptor (osteoprotegerin, OPG). Whilst RANK is expressed by osteoclasts, RANK-L and OPG are expressed by osteoblasts. The long chain polyunsaturated fatty acid (LCPUFA) arachidonic acid (AA, 20:4n-6) and its metabolite prostaglandin E2 (PGE2), are pro-inflammatory and PGE2 is a...

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Format

Research paper

Research format

Journal article

Date created

2008-02

Creator

Poulsen, Raewyn / Wolber, FM / Moughan, PJ / Kruger, MC

URL

http://hdl.handle.net/2292/29555

Related subjects

3T3 Cells / Cell Membrane / Osteoblasts / Animals / Mice / Fatty Acids, Unsaturated / Enzyme-Linked Immunosorbent Assay / Cell Cycle / RANK Ligand / Osteoprotegerin

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