Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells

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Title

Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Background: The vasculature of the brain is composed of endothelial cells, pericytes and astrocytic processes. The endothelial cells are the critical interface between the blood and the CNS parenchyma and are a critical component of the blood-brain barrier (BBB). These cells are innately programmed to respond to a myriad of inflammatory cytokines or other danger signals. IL-1β and TNFα are well recognised pro-inflammatory mediators, and here, we provide compelling evidence that they regulate ...

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Format

Research paper

Research format

Journal article

Date created

2015-07-08

Creator

OCarroll, Simon / Kho, Dan / Wiltshire, R / Nelson, Vicky / Mugisho, Odunayo / Johnson, Rebecca / Angel, Catherine / Graham, Euan

URL

http://hdl.handle.net/2292/30036

Related subjects

Brain / Cell Line / Endothelial Cells / Humans / Encephalitis / Tumor Necrosis Factor-alpha / Intercellular Adhesion Molecule-1 / Vascular Cell Adhesion Molecule-1 / Cytokines / Immunophenotyping / Phenotype / Interleukin-1beta / Microvessels / Tight Junction Proteins

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