Repletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution

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Title

Repletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution

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Directory of Open Access Journals

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Directory of Open Access Journals

Description

Objective: Dietary protein dilution (PD) has been associated with metabolic advantages such as improved glucose homeostasis and increased energy expenditure. This phenotype involves liver-induced release of FGF21 in response to amino acid insufficiency; however, it has remained unclear whether dietary dilution of specific amino acids (AAs) is also required. Circulating branched chain amino acids (BCAAs) are sensitive to protein intake, elevated in the serum of obese humans and mice and though...

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Format

Research paper

Date created

2017-08-01

Creator

Adriano Maida / Jessica S.K. Chan / Kim A. Sjøberg / Annika Zota / Dieter Schmoll / Bente Kiens / Stephan Herzig / Adam J. Rose

Contributing partner

Molecular Metabolism

URL

http://www.sciencedirect.com/science/article/pii/S2212877817303824

Related subjects

BCAA / Dietary protein / FGF21 / mTORC1 / Diabetes / Internal medicine

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You can learn more about the rights status of this item at: http://www.elsevier.com/journals/molecular-metabolism/2212-8778/open-access-journal

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