Research paper

Epigenetic changes in the hypothalamic proopiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition.

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Title
Epigenetic changes in the hypothalamic proopiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition.
Content partner
The University of Auckland Library
Collection
ResearchSpace@Auckland
Description

Maternal food restriction is associated with the development of obesity in offspring. This study examined how maternal undernutrition in sheep affects the fetal hypothalamic glucocorticoid receptor (GR) and the appetite-regulating neuropeptides, proopiomelanocortin (POMC) and neuropeptide Y, which it regulates. In fetuses from ewes undernourished from -60 to +30 d around conception, there was increased histone H3K9 acetylation (1.63-fold) and marked hypomethylation (62% decrease) of the POMC ...

Format
Research paper
Research format
Journal article
Date created
2010-08
Creator
Stevens, A / Begum, G / Cook, A / Connor, Kristin / Rumball, C / Oliver, Mark / Challis, J / Bloomfield, Francis / White, A
URL
http://hdl.handle.net/2292/32380
Related subjects
Animals / Epigenesis, Genetic / Female / Fertilization / Fetal Nutrition Disorders / Fetus / Histone Acetyltransferases / Histones / Hypothalamo-Hypophyseal System / Hypothalamus / Malnutrition / Maternal Nutritional Physiological Phenomena / Maternal-Fetal Exchange / Pituitary-Adrenal System / Pregnancy / Prenatal Exposure Delayed Effects / Pro-Opiomelanocortin / Receptors, Glucocorticoid / Sheep

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