Mitochondrial dysfunction in steatotic rat livers occurs because a defect in complex i makes the liver susceptible to prolonged cold ischemia

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Title

Mitochondrial dysfunction in steatotic rat livers occurs because a defect in complex i makes the liver susceptible to prolonged cold ischemia

Content partner

The University of Auckland Library

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ResearchSpace@Auckland

Description

Steatotic livers are susceptible to cold ischemia, which is thought to be secondary to mitochondrial dysfunction. Ischemic preconditioning (IPC) has been reported to improve liver function in the setting of warm ischemia/reperfusion injury, but the effect of IPC on steatotic liver mitochondrial function (MF) with cold ischemia has not been previously evaluated. We aimed to evaluate MF with various severities of hepatic steatosis after various durations of cold ischemia storage with or without...

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Format

Research paper

Research format

Journal article

Date created

2015-03

Creator

Chu, MJJ / Hickey, Anthony / Jiang, Yannan / Petzer, A / Bartlett, Adam / Phillips, Anthony

URL

http://hdl.handle.net/2292/33933

Related subjects

Animals / Cold Ischemia / Disease Models, Animal / Electron Transport Complex I / Ischemic Preconditioning / Liver / Male / Mitochondria, Liver / Non-alcoholic Fatty Liver Disease / Rats, Sprague-Dawley / Reperfusion Injury / Risk Factors / Severity of Illness Index / Time Factors

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