Inhibitors of pan-PI3K Signaling Synergize with BRAF or MEK Inhibitors to Prevent BRAF-Mutant Melanoma Cell Growth

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Title

Inhibitors of pan-PI3K Signaling Synergize with BRAF or MEK Inhibitors to Prevent BRAF-Mutant Melanoma Cell Growth

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

BRAF and MEK inhibitors have improved outcomes for patients with BRAF-mutant melanoma, but their efficacy is limited by both intrinsic and acquired resistances. Activation of the PI3K pathway can mediate resistance to these agents, providing a strong rationale for combination therapy in melanoma. Here, a panel of nine low-passage human metastatic melanoma cell lines with BRAF mutations was tested in cell proliferation and protein expression assays for sensitivity to inhibitors of MEK (selumet...

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Format

Research paper

Research format

Journal article

Date created

2015-06

Creator

Sweetlove, M / Wrightson, E / Kolekar, Sharada / Rewcastle, Gordon / Baguley, Bruce / Shepherd, Peter / Jamieson, Stephen

URL

http://hdl.handle.net/2292/34179

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