An in vivo antilymphatic screen in zebrafish identifies novel inhibitors of mammalian lymphangiogenesis and lymphatic-mediated metastasis

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Title

An in vivo antilymphatic screen in zebrafish identifies novel inhibitors of mammalian lymphangiogenesis and lymphatic-mediated metastasis

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

The growth of new lymphatic vessels (lymphangiogenesis) in tumors is an integral step in the metastatic spread of tumor cells, first to the sentinel lymph nodes that surround the tumor and then elsewhere in the body. Currently, no selective agents designed to prevent lymphatic vessel growth have been approved for clinical use, and there is an important potential clinical niche for antilymphangiogenic agents. Using a zebrafish phenotype-based chemical screen, we have identified drug compounds,...

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Format

Research paper

Research format

Journal article

Date created

2014-10

Creator

Astin, Jonathan / Jamieson, Stephen / Eng, TCY / Flores, MV / Misa, JP / Chien, A / Crosier, Kathryn / Crosier, Philip

URL

http://hdl.handle.net/2292/34200

Related subjects

Lymph Nodes / Endothelial Cells / Animals / Mice, Inbred C57BL / Zebrafish / Humans / Mice / Neoplasms / Lymphatic Metastasis / Isoxazoles / Cinnarizine / Flunarizine / Kaempferols / Receptor Protein-Tyrosine Kinases / Antineoplastic Agents / Random Allocation / Lymphangiogenesis / Female

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