Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels

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Title

Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Age of Huntington's disease (HD) motoric onset is strongly related to the number of CAG trinucleotide repeats in the huntingtin gene, suggesting that biological tissue age plays an important role in disease etiology. Recently, a DNA methylation based biomarker of tissue age has been advanced as an epigenetic aging clock. We sought to inquire if HD is associated with an accelerated epigenetic age. DNA methylation data was generated for 475 brain samples from various brain regions of 26 HD case...

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Format

Research paper

Research format

Journal article

Date created

2016-07-27

Creator

Horvath, S / Langfelder, P / Kwak, S / Aaronson, J / Rosinski, J / Vogt, TF / Eszes, M / Faull, Richard / Curtis, Maurice / Waldvogel, Henry / Choi, O-W / Tung, S / Vinters, HV / Coppola, G / Yang, XW

URL

http://hdl.handle.net/2292/35531

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