Effect of global cardiac ischemia on human ventricular fibrillation: Insights from a multi-scale mechanistic model of the human heart

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Title

Effect of global cardiac ischemia on human ventricular fibrillation: Insights from a multi-scale mechanistic model of the human heart

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Acute regional ischemia in the heart can lead to cardiac arrhythmias such as ventricular fibrillation (VF), which in turn compromise cardiac output and result in secondary global cardiac ischemia. The secondary ischemia may influence the underlying arrhythmia mechanism. A recent clinical study documents the effect of global cardiac ischaemia on the mechanisms of VF. During 150 seconds of global ischemia the dominant frequency of activation decreased, while after reperfusion it increased rapid...

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Format

Research paper

Research format

Journal article

Date created

2014-11

Creator

Kazbanov, IV / Clayton, RH / Nash, Martyn / Bradley, Christopher / Paterson, DJ / Hayward, MP / Taggart, P / Panfilov, AV

URL

http://hdl.handle.net/2292/35232

Related subjects

Myocardium / Heart / Humans / Ventricular Fibrillation / Myocardial Ischemia / Hyperkalemia / Imaging, Three-Dimensional / Models, Cardiovascular / Computer Simulation / Hypoxia

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