Increased cardiac work provides a link between systemic hypertension and heart failure

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Title

Increased cardiac work provides a link between systemic hypertension and heart failure

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

The spontaneously hypertensive rat (SHR) is an established model of human hypertensive heart disease transitioning into heart failure. The study of the progression to heart failure in these animals has been limited by the lack of longitudinal data. We used MRI to quantify left ventricular mass, volume, and cardiac work in SHRs at age 3 to 21 month and compared these indices to data from Wistar-Kyoto (WKY) controls. SHR had lower ejection fraction compared with WKY at all ages, but there was n...

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Format

Research paper

Research format

Journal article

Date created

2017-01

Creator

Wilson, Alexander / Wang, Yang / Sands, Gregory / Young, Alistair / Nash, Martyn / Le Grice, Ian

URL

http://hdl.handle.net/2292/35214

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