Renal denervation in male rats with heart failure improves ventricular sympathetic nerve innervation and function

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Title

Renal denervation in male rats with heart failure improves ventricular sympathetic nerve innervation and function

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Heart failure is characterized by the loss of sympathetic innervation to the ventricles, contributing to impaired cardiac function and arrhythmogenesis. We hypothesized that renal denervation (RDx) would reverse this loss. Male Wistar rats underwent myocardial infarction (MI) or sham surgery and progressed into heart failure for 4 wk before receiving bilateral RDx or sham RDx. After additional 3 wk, left ventricular (LV) function was assessed, and ventricular sympathetic nerve fiber density w...

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Format

Research paper

Research format

Journal article

Date created

2017-03

Creator

Pinkham, MI / Loftus, MT / Amirapu, Satya / Guild, Sarah-Jane / Quill, G / Woodward, WR / Habecker, BA / Barrett, Carolyn

URL

http://hdl.handle.net/2292/35755

Related subjects

Kidney / Heart Ventricles / Animals / Rats / Rats, Wistar / Ventricular Dysfunction, Left / Stroke Volume / Treatment Outcome / Sympathectomy / Male / Heart Failure

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