Structure-Activity Relationships of the Bioactive Thiazinoquinone Marine Natural Products Thiaplidiaquinones A and B

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Title

Structure-Activity Relationships of the Bioactive Thiazinoquinone Marine Natural Products Thiaplidiaquinones A and B

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The University of Auckland Library

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ResearchSpace@Auckland

Description

In an effort to more accurately define the mechanism of cell death and to establish structure-activity relationship requirements for the marine meroterpenoid alkaloids thiaplidiaquinones A and B, we have evaluated not only the natural products but also dioxothiazine regioisomers and two precursor quinones in a range of bioassays. While the natural products were found to be weak inducers of ROS in Jurkat cells, the dioxothiazine regioisomer of thiaplidiaquinone A and a synthetic precursor to t...

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Format

Research paper

Research format

Journal article

Date created

2015-08-10

Creator

Harper, Jacquie / Khalil, Iman / Shaw, L / Bourguet-Kondracki, M-L / Dubois, J / Valentin, A / Barker, David / Copp, Brent

URL

http://hdl.handle.net/2292/36055

Related subjects

Cell Line, Tumor / Jurkat Cells / Humans / Terpenes / Quinones / Biological Products / Apoptosis / Cell Proliferation / Structure-Activity Relationship / Aquatic Organisms

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