Linkages between changes in the 3D organization of the genome and transcription during myotube differentiation in vitro

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Title

Linkages between changes in the 3D organization of the genome and transcription during myotube differentiation in vitro

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The University of Auckland Library

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Description

BACKGROUND: The spatial organization of eukaryotic genomes facilitates and reflects the underlying nuclear processes that are occurring in the cell. As such, the spatial organization of a genome represents a window on the genome biology that enables analysis of the nuclear regulatory processes that contribute to mammalian development. METHODS: In this study, Hi-C and RNA-seq were used to capture the genome organization and transcriptome in mouse muscle progenitor cells (C2C12 myoblasts) befor...

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Format

Research paper

Research format

Journal article

Date created

2017-04-05

Creator

Doynova, MD / Markworth, JF / Cameron-Smith, David / Vickers, Mark / O'Sullivan, Justin

URL

http://hdl.handle.net/2292/36105

Related subjects

Development / Genome organization / Hi-C / Muscle / Transcriptome

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