Considerations on mTOR regulation at serine 2448: Implications for muscle metabolism studies

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Title

Considerations on mTOR regulation at serine 2448: Implications for muscle metabolism studies

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

The mammalian target of rapamycin (mTOR) complex exerts a pivotal role in protein anabolism and cell growth. Despite its importance, few studies adequately address the complexity of phosphorylation of the mTOR protein itself to enable conclusions to be drawn on the extent of kinase activation following this event. In particular, a large number of studies in the skeletal muscle biology field have measured Serine 2448 (Ser2448) phosphorylation as a proxy of mTOR kinase activity. However, the ev...

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Format

Research paper

Research format

Journal article

Date created

2017-07

Creator

Figueiredo, VC / Markworth, JF / Cameron-Smith, David

URL

http://hdl.handle.net/2292/36110

Related subjects

Muscles / Animals / Humans / Serine / Exercise / Phosphorylation / TOR Serine-Threonine Kinases / Biomarkers

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