Investigation of indolglyoxamide and indolacetamide analogues of polyamines as antimalarial and antitrypanosomal agents

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Title

Investigation of indolglyoxamide and indolacetamide analogues of polyamines as antimalarial and antitrypanosomal agents

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The University of Auckland Library

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Description

Pure compound screening has previously identified the indolglyoxy lamidospermidine ascidian metabolites didemnidine A and B (2 and 3) to be weak growth inhibitors of Trypanosoma brucei rhodesiense (IC50 59 and 44 μM, respectively) and Plasmodium falciparum (K1 dual drug resistant strain) (IC50 41 and 15 μM, respectively), but lacking in selectivity (L6 rat myoblast, IC50 24 μM and 25 μM, respectively). To expand the structure-activity relationship of this compound class towards both parasites...

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Format

Research paper

Research format

Journal article

Date created

2014-05-28

Creator

Wang, Jiayi / Kaiser, M / Copp, Brent

URL

http://hdl.handle.net/2292/36123

Related subjects

Animals / Antimalarials / Cell Line / Female / Inhibitory Concentration 50 / Mice / Myoblasts / Parasitic Sensitivity Tests / Plasmodium falciparum / Polyamines / Rats / Structure-Activity Relationship / Trypanocidal Agents / Trypanosoma brucei rhodesiense

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