Vinpocetine regulates cation channel permeability of inner retinal neurons in the ischaemic retina

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Title

Vinpocetine regulates cation channel permeability of inner retinal neurons in the ischaemic retina

Content partner

The University of Auckland Library

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ResearchSpace@Auckland

Description

Vinpocetine is a natural drug which exerts neuroprotective effects in ischaemia of the brain through actions on cation channels, glutamate receptors and other pathways. This study investigated the effect of vinpocetine on cation channel permeability of inner retinal neurons after acute retinal metabolic insult. We focused on amacrine and ganglion cells immunoreactive for calretinin or parvalbumin due to their previously documented susceptibility to ischaemia. Using the probe, 1-amino-4-guanid...

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Format

Research paper

Research format

Journal article

Date created

2014-01

Creator

Nivison-Smith, L / Acosta Etchebarne, Monica / Misra, Stuti / O'Brien, BJ / Kalloniatis, Michael

URL

http://hdl.handle.net/2292/36727

Related subjects

Agmatine / Cation channel / Ischaemia / Retina / Vinpocetine / Animals / Calcium Channel Blockers / Ion Channels / Ischemia / Organ Culture Techniques / Permeability / Rats / Rats, Sprague-Dawley / Receptors, N-Methyl-D-Aspartate / Retinal Neurons / Vinca Alkaloids

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