Sildenafil alters retinal function in mouse carriers of Retinitis Pigmentosa

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Title

Sildenafil alters retinal function in mouse carriers of Retinitis Pigmentosa

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Sildenafil, the active ingredient in Viagra, has been reported to cause transient visual disturbance from inhibition of phosphodiesterase 6 (PDE6), a key enzyme in the visual phototransduction pathway. This study investigated the effects of sildenafil on the rd1(+/-) mouse, a model for carriers of Retinitis Pigmentosa which exhibit normal vision but may have a lower threshold for cellular stress caused by sildenafil due to a heterozygous mutation in PDE6. Sildenafil caused a dose-dependent de...

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Format

Research paper

Research format

Journal article

Date created

2014-11

Creator

Nivison-Smith, L / Zhu, Y / Whatham, A / Bui, BV / Fletcher, EL / Acosta Etchebarne, Monica / Kalloniatis, Michael

URL

http://hdl.handle.net/2292/36726

Related subjects

Retina / Animals / Mice, Inbred C57BL / Mice / Retinitis Pigmentosa / Disease Models, Animal / Sulfones / Piperazines / Purines / Glial Fibrillary Acidic Protein / Cytochromes c / Electroretinography / Fluorescent Antibody Technique, Indirect / In Situ Nick-End Labeling / Dose-Response Relationship, Drug / Heterozygote / Female / Male / Retinal Bipolar Cells / Photoreceptor Cells, Vertebrate / Phosphodiesterase 5 Inhibitors

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• Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/0014-4835/ https://www.elsevier.com/about/our-business/policies/sharing
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