Development, validation and application of a stability indicating HPLC method to quantify lidocaine from polyethylene-co-vinyl acetate (EVA) matrices and biological fluids

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Title

Development, validation and application of a stability indicating HPLC method to quantify lidocaine from polyethylene-co-vinyl acetate (EVA) matrices and biological fluids

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

An efficient and cost-effective quantification procedure for lidocaine by HPLC has been developed to estimate lidocaine from an EVA matrix, plasma, peritoneal fluid and intra-articular fluid (IAF). This method guarantees the resolution of lidocaine from the degradation products obtained from alkaline and oxidative stress. Chromatographic separation of lidocaine was achieved with a retention time of 7 min using a C18 column with a mobile phase comprising acetonitrile and potassium dihydrogen p...

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Format

Research paper

Research format

Journal article

Date created

2017-09

Creator

Bhusal, P / Sharma, Manisha / Harrison, Jeffrey / Procter, G / Andrews, G / Jones, DS / Hill, Andrew / Svirskis, Darren

URL

http://hdl.handle.net/2292/36714

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