Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis.

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Title

Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Exposure to retinoids for the treatment of acne has been linked to the etiology of inflammatory bowel disease (IBD). The intestinal mucus layer is an important structural barrier that is disrupted in IBD. Retinoid-induced alteration of mucus physiology has been postulated as a mechanism linking retinoid treatment to IBD; however, there is little direct evidence for this interaction. The zebrafish larva is an emerging model system for investigating the pathogenesis of IBD. Importantly, this sy...

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Format

Research paper

Research format

Journal article

Date created

2012-07

Creator

Oehlers, Stefan H / Flores, Maria Vega / Hall, Christopher / Crosier, Kathryn / Crosier, Philip

URL

http://hdl.handle.net/2292/41532

Related subjects

Intestines / Neutrophils / Mucus / Animals / Zebrafish / Mice / Enterocolitis / Disease Models, Animal / Inflammation / Trinitrobenzenesulfonic Acid / Tretinoin / Dextran Sulfate / Mucins / Larva / Phenotype / Metagenome

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