Epidermal cells help coordinate leukocyte migration during inflammation through fatty acid-fuelled matrix metalloproteinase production.

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Title

Epidermal cells help coordinate leukocyte migration during inflammation through fatty acid-fuelled matrix metalloproteinase production.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

In addition to satisfying the metabolic demands of cells, mitochondrial metabolism helps regulate immune cell function. To date, such cell-intrinsic metabolic-immunologic cross-talk has only been described operating in cells of the immune system. Here we show that epidermal cells utilize fatty acid β-oxidation to fuel their contribution to the immune response during cutaneous inflammation. By live imaging metabolic and immunological processes within intact zebrafish embryos during cutaneous i...

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Format

Research paper

Research format

Journal article

Date created

2014-01

Creator

Hall, Christopher / Boyle, Rachel H / Sun, Xueying / Wicker, Sophie M / Misa, June P / Krissansen, Geoffrey / Print, Cristin / Crosier, Kathryn / Crosier, Philip

URL

http://hdl.handle.net/2292/41538

Related subjects

Epidermis / Leukocytes / Mitochondria / Macrophages / Animals / Zebrafish / Mice / Salmonella Infections, Animal / Dermatitis, Atopic / Disease Models, Animal / Inflammation / Reactive Oxygen Species / Fatty Acids / Zebrafish Proteins / Receptors, Glucocorticoid / RNA, Messenger / Glucocorticoids / Survival Analysis / Gene Expression Profiling / Signal Transduction / Cell Movement / Neutrophil Infiltration / Oxidation-Reduction / Larva / Matrix Metalloproteinase 9 / Morpholinos

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