Magnesium sulfate and sex differences in cardiovascular and neural adaptations during normoxia and asphyxia in preterm fetal sheep.

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Title

Magnesium sulfate and sex differences in cardiovascular and neural adaptations during normoxia and asphyxia in preterm fetal sheep.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Magnesium sulfate (MgSO4) is recommended for preterm neuroprotection, preeclampsia, and preterm labor prophylaxis. There is an important, unmet need to carefully test clinical interventions in both sexes. Therefore, we aimed to investigate cardiovascular and neurophysiological adaptations to MgSO4 during normoxia and asphyxia in preterm male and female fetal sheep. Fetuses were instrumented at 98 ± 1 days of gestation (term = 147 days). At 104 days, unanesthetized fetuses were randomly assign...

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Format

Research paper

Research format

Journal article

Date created

2018-08

Creator

Galinsky, Robert / Dhillon, Simerdeep K / Lear, Christopher / Yamaguchi, Kyohei / Wassink, Guido / Gunn, Alistair / Bennet, Laura

URL

http://hdl.handle.net/2292/43036

Related subjects

Cardiovascular System / Brain / Animals / Sheep, Domestic / Asphyxia / Disease Models, Animal / Magnesium Sulfate / Neuroprotective Agents / Electroencephalography / Prenatal Diagnosis / Sex Factors / Adaptation, Physiological / Fetal Movement / Gestational Age / Heart Rate, Fetal / Female / Male / Hemodynamics / Brain Waves / Arterial Pressure

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