MRP2 as a Targetable Oxaliplatin Resistance Factor in Gastrointestinal Cancer

About this item

Title

MRP2 as a Targetable Oxaliplatin Resistance Factor in Gastrointestinal Cancer

Content partner

Auckland University of Technology

Collection

Tuwhera

Description

Despite the severe adverse effects, toxicity and limited efficacy due to the development of multidrug resistance (MDR), chemotherapy is still the treatment of choice for most of the cancer patients. One of the formidable MDR mechanisms is the up-regulation of various efflux pumps, known as the ATP binding cassette (ABC) transporters, which can efficiently remove drugs from the cell, thus causing the decreased efficacy of chemotherapeutic drugs. The platinum-based regimens are important in the...

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Format

Research paper

Research format

Thesis

Thesis level

Doctoral

Date created

2018

Creator

Biswas, Riya

URL

https://openrepository.aut.ac.nz/handle/10292/12052

Related subjects

MRP2 / Oxaliplatin / Drug resistance / Gastrointestinal cancer / Myricetin / ABC transporter

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