Changes in clinical disease activity are weakly linked to changes in MRI inflammation on treat-to-target escalation of therapy in rheumatoid arthritis.

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Title

Changes in clinical disease activity are weakly linked to changes in MRI inflammation on treat-to-target escalation of therapy in rheumatoid arthritis.

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The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Rheumatoid arthritis (RA) treat-to-target (T2T) regimens often use the disease activity score (28 joints) incorporating C-reactive protein (DAS28CRP) as an outcome measure. We compared changes in the DAS28CRP with changes in magnetic resonance imaging (MRI) inflammation on treatment escalation.Eighty seropositive RA patients with active disease were enrolled. Group A (N = 57) escalated to another conventional disease-modifying therapy (cDMARD) combination, and Group B (N = 23) to anti-TNF the...

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Format

Research paper

Research format

Journal article

Date created

2017-10-24

Creator

McQueen, Fiona / Chapman, Peter / Pollock, Terina / D'Souza, Dena / Lee, Arier / Dalbeth, Nicola / Stamp, Lisa / Lindsay, Karen / Doyle, Anthony

URL

http://hdl.handle.net/2292/44364

Related subjects

Wrist Joint / Humans / Arthritis, Rheumatoid / Inflammation / Tumor Necrosis Factor-alpha / C-Reactive Protein / Antirheumatic Agents / Magnetic Resonance Imaging / Drug Therapy, Combination / Severity of Illness Index / Prospective Studies / Adult / Aged / Aged, 80 and over / Middle Aged / Outcome Assessment (Health Care) / Female / Male / Young Adult / Adalimumab

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