Synthetic peptides designed to modulate adiponectin assembly improve obesity-related metabolic disorders.

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Title

Synthetic peptides designed to modulate adiponectin assembly improve obesity-related metabolic disorders.

Content partner

The University of Auckland Library

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ResearchSpace@Auckland

Description

BACKGROUND AND PURPOSE:Adiponectin, an adipokine possessing profound insulin-sensitizing and anti-inflammatory properties, is a potent biotherapeutic agent . The trimeric adiponectin subunit assembles into hexameric and functionally important higher molecular weight (HMW) forms, controlled by the endoplasmic reticulum protein 44 (ERp44). Obesity-induced ER stress decreases the HMW form in serum, contributing to the development of insulin resistance and Type 2 diabetes. In this study, a panel ...

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Format

Research paper

Research format

Journal article

Date created

2017-12

Creator

Hampe, Lutz / Xu, Cheng / Harris, Paul / Chen, Jie / Liu, Ming / Middleditch, Martin / Radjainia, Mazdak / Wang, Yu / Mitra, Alok

URL

http://hdl.handle.net/2292/44244

Related subjects

3T3-L1 Cells / Animals / Mice, Inbred C57BL / Mice / Metabolic Diseases / Diabetes Mellitus, Type 2 / Insulin Resistance / Obesity / Disease Models, Animal / Peptides / Membrane Proteins / Molecular Chaperones / Energy Metabolism / Drug Design / Molecular Weight / Male / Adiponectin / Endoplasmic Reticulum Stress

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