Sphere-forming cells from peripheral cornea demonstrate the ability to repopulate the ocular surface.

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Title

Sphere-forming cells from peripheral cornea demonstrate the ability to repopulate the ocular surface.

Content partner

The University of Auckland Library

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ResearchSpace@Auckland

Description

The limbus forms the outer rim of the cornea at the corneoscleral junction and harbours a population of stem cells for corneal maintenance. Injuries to the limbus, through disease or accidents such as chemical injuries or burns, may lead to significant visual impairment due to depletion of the native stem cells of the tissue.Sphere-forming cells were isolated from peripheral cornea for potential use as transplantable elements for limbal stem cell repopulation and limbal reconstruction. Immuno...

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Format

Research paper

Research format

Journal article

Date created

2016-06

Creator

Mathan, Jeremy John / Ismail, Salim / McGhee, Jennifer / McGhee, Charles / Sherwin, Trevor

URL

http://hdl.handle.net/2292/42740

Related subjects

Epithelium, Corneal / Limbus Corneae / Spheroids, Cellular / Stem Cells / Humans / Cadaver / Vimentin / Proteoglycans / P-Glycoprotein / Laminin / Neoplasm Proteins / Tumor Suppressor Proteins / Proliferating Cell Nuclear Antigen / Transcription Factors / Stem Cell Transplantation / Tissue Culture Techniques / Cell Differentiation / Cell Proliferation / Cell Movement / Gene Expression / Receptor, Notch1 / Keratin-3 / Biomarkers / ATP Binding Cassette Transporter, Sub-Family G, Member 2

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