α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patients.

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Title

α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patients.

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Parkinson's disease (PD) is characterized by the presence of inclusions known as Lewy bodies, which mainly consist of α-synuclein (α-syn) aggregates. There is growing evidence that α-syn self-propagates in non-neuronal cells, thereby contributing to the progression and spread of PD pathology in the brain. Tunneling nanotubes (TNTs) are long, thin, F-actin-based membranous channels that connect cells and have been proposed to act as conduits for α-syn transfer between cells. SH-SY5Y cells and ...

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Format

Research paper

Research format

Journal article

Date created

2017-02-23

Creator

Dieriks, Birger / Park, In / Fourie, Chantelle / Faull, Richard / Dragunow, Michael / Curtis, Maurice

URL

http://hdl.handle.net/2292/42928

Related subjects

Pericytes / Brain / Neurons / Lewy Bodies / Cells, Cultured / Cell Membrane / Humans / Parkinson Disease / Microscopy, Confocal / Microscopy, Electron, Scanning / Coculture Techniques / Mitosis / Protein Transport / Nanotubes / alpha-Synuclein / Time-Lapse Imaging

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