Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation.

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Title

Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Gout is the most common inflammatory arthritis affecting men. Acute gouty inflammation is triggered by monosodium urate (MSU) crystal deposition in and around joints that activates macrophages into a proinflammatory state, resulting in neutrophil recruitment. A complete understanding of how MSU crystals activate macrophages in vivo has been difficult because of limitations of live imaging this process in traditional animal models. By live imaging the macrophage and neutrophil response to MSU ...

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Format

Research paper

Research format

Journal article

Date created

2018-05

Creator

Hall, Christopher / Sanderson, Leslie E / Lawrence, Lisa M / Pool, Bregtina / van der Kroef, Maarten / Ashimbayeva, Elina / Britto, Denver / Harper, Jacquie L / Lieschke, Graham J / Astin, Jonathan / Crosier, Kathryn / Dalbeth, Nicola / Crosier, Philip

URL

http://hdl.handle.net/2292/43037

Related subjects

Neutrophils / Macrophages / Animals / Mice, Inbred BALB C / Animals, Genetically Modified / Zebrafish / Humans / Mice / Gout / Disease Models, Animal / Inflammation / Reactive Oxygen Species / Uric Acid / Fatty Acids / Oxidation-Reduction / Male / THP-1 Cells

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