Connexin hemichannel blockade improves survival of striatal GABA-ergic neurons after global cerebral ischaemia in term-equivalent fetal sheep.

About this item

Title

Connexin hemichannel blockade improves survival of striatal GABA-ergic neurons after global cerebral ischaemia in term-equivalent fetal sheep.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Basal ganglia injury at term remains a major cause of disability, such as cerebral palsy. In this study we tested the hypotheses that blockade of astrocytic connexin hemichannels with a mimetic peptide would improve survival of striatal phenotypic neurons after global cerebral ischaemia in term-equivalent fetal sheep, and that neuronal survival would be associated with electrophysiological recovery. Fetal sheep (0.85 gestation) were randomly assigned to receive a short or long (1 or 25 h) int...

Read more

Format

Research paper

Research format

Journal article

Date created

2017-07-24

Creator

Galinsky, Robert / Davidson, Joanne / Lear, Christopher / Bennet, Laura / Green, Colin / Gunn, Alistair

URL

http://hdl.handle.net/2292/44194

Related subjects

Corpus Striatum / Animals / Sheep / Brain Ischemia / Disease Models, Animal / Peptides / Connexin 43 / Random Allocation / Pregnancy / Female / Infusions, Intraventricular / GABAergic Neurons / Calbindin 1 / Calbindin 2 / Biological Mimicry

What is the copyright status of this item?

Share, Modify, Use commercially

See below for specifics about how you may use this item.

More Information

The University of Auckland Library has this to say about the rights status of this item:

Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.

You can learn more about the rights status of this item at:

• https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
• https://creativecommons.org/licenses/by/4.0/
• http://purl.org/eprint/accessRights/OpenAccess

What can I do with this item?

You must always check with The University of Auckland Library to confirm the specific terms of use, but this is our understanding:

Non-infringing use

NZ Copyright law does not prevent every use of a copyright work. You should consider what you can and cannot do with a copyright work.

Share it

This item is suitable for copying and sharing with others, without further permission.

Modify it

This item is suitable for modifying, remixing and building upon, without further permission.

Use it commercially

This item is suitable for commercial use, without further permission.