Research paper
Cyclic-RGDyC functionalized liposomes for dual-targeting of tumor vasculature and cancer cells in glioblastoma: An in vitro boron neutron capture therapy study.
About this item
- Title
- Cyclic-RGDyC functionalized liposomes for dual-targeting of tumor vasculature and cancer cells in glioblastoma: An in vitro boron neutron capture therapy study.
- Content partner
- The University of Auckland Library
- Collection
- ResearchSpace@Auckland
- Description
The efficacy of boron neutron capture therapy depends on the selective delivery of 10B to the target. Integrins αvβ3 are transmembrane receptors over-expressed in both glioblastoma cells and its neovasculature. In this study, a novel approach to dual-target glioblastoma vasculature and tumor cells was investigated. Liposomes (124 nm) were conjugated with a αvβ3 ligand, cyclic arginine-glycine-aspartic acid-tyrosine-cysteine peptide (c(RGDyC)-LP) (1% molar ratio) through thiol-maleimide coupli...
- Format
- Research paper
- Research format
- Journal article
- Date created
- 2017-05
- Creator
- Kang, Weirong / Svirskis, Darren / Sarojini Amma, Vijayalekshmi / McGregor, Ailsa / Bevitt, Joseph / Wu, Zimei
- URL
- http://hdl.handle.net/2292/43468
- Related subjects
- Cell Line, Tumor / Endothelial Cells / Humans / Glioblastoma / Neovascularization, Pathologic / Peptides, Cyclic / Integrin alphaVbeta3 / Liposomes / Boron Neutron Capture Therapy / Drug Compounding / Drug Stability / Cell Survival / Drug Liberation
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