Interaction between leukocyte aldo-keto reductase 1C3 activity, genotypes, biological, lifestyle and clinical features in a prostate cancer cohort from New Zealand

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Title

Interaction between leukocyte aldo-keto reductase 1C3 activity, genotypes, biological, lifestyle and clinical features in a prostate cancer cohort from New Zealand

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IntroductionAldo-keto reductase 1C3 (AKR1C3) is known for multiple functions including its catalytic activity towards producing extra-testicular androgen. The present study is towards understanding interaction between biological, lifestyle and genetic impacts of AKR1C3 and their influence on clinical factors in a prostate cancer (PC) cohort from New Zealand (NZ).MethodCharacteristics of 516 PC patients were collected from the Auckland Regional Urology Facility, NZ. These men were genotyped fo...

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Date created

24 May, 2019

Creator

Nishi Karunasinghe / Eva Symes / Amy Gamage / Alice Wang / Pam Murray / Shuotun Zhu / Megan Goudie / Jonathan Masters / Lynnette R. Ferguson

URL

https://doi.org/10.1371/journal.pone.0217373

Related subjects

AKR 1C / GG genotypes / SNP / prostate cancer cohort / PC diagnosis / AKR 1C rs 12529 GG / NZ / New Zealand Introduction Aldo-keto reductase 1 C 3 / AKR 1C rs 12529 / CC / 516 PC patients / CG genotype carriers / AKR 1C rs 12529 CG / correlation coefficient 0.20 / leukocyte aldo-keto reductase 1 C 3 activity / PSA / Auckland Regional Urology Facility / leukocyte AKR 1C activity / Biochemistry / Cell Biology / Genetics / Biotechnology / Environmental Sciences not elsewhere classified / Immunology / Cancer / Mental Health

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