LPS and TNF alpha modulate AMPA/NMDA receptor subunit expression and induce PGE2 and glutamate release in preterm fetal ovine mixed glial cultures.

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Title

LPS and TNF alpha modulate AMPA/NMDA receptor subunit expression and induce PGE2 and glutamate release in preterm fetal ovine mixed glial cultures.

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The University of Auckland Library

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ResearchSpace@Auckland

Description

BACKGROUND: White matter injury (WMI) is the major antecedent of cerebral palsy in premature infants, and is often associated with maternal infection and the fetal inflammatory response. The current study explores the therapeutic potential of glutamate receptor blockade or cyclooxygenase-2 (COX-2) inhibition for inflammatory WMI. METHODS: Using fetal ovine derived mixed glia cultures exposed to tumour necrosis factor-α (TNF-α) or lipopolysaccharide (LPS), the expression of alpha-amino-3-hydro...

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Format

Research paper

Research format

Journal article

Date created

2013-01

Creator

Weaver-Mikaere, Luke / Gunn, Alistair / Mitchell, Murray D / Bennet, Laura / Fraser, Mhoyra

URL

http://hdl.handle.net/2292/41300

Related subjects

Neuroglia / Cells, Cultured / Fetus / Animals / Sheep / Encephalitis / Brain Injuries / Disease Models, Animal / Lipopolysaccharides / Dinoprostone / Glutamic Acid / Tumor Necrosis Factor-alpha / Receptors, Glutamate / Receptors, AMPA / Receptors, N-Methyl-D-Aspartate / Radioimmunoassay / Blotting, Western / Immunohistochemistry / Cyclooxygenase 2 / Real-Time Polymerase Chain Reaction

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