Delayed Varenicline Administration Reduces Inflammation and Improves Forelimb Use Following Experimental Stroke.

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Title

Delayed Varenicline Administration Reduces Inflammation and Improves Forelimb Use Following Experimental Stroke.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Pharmacological activation of the cholinergic anti-inflammatory pathway (CAP), specifically by activating α7 nicotinic acetylcholine receptors, has been shown to confer short-term improvements in outcome. Most studies have investigated administration within 24 hours of stroke, and few have investigated drugs approved for use in human patients. We investigated whether delayed administration of varenicline, a high-affinity agonist at α7 nicotinic receptors and an established therapy for nicotin...

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Format

Research paper

Research format

Journal article

Date created

2017-12

Creator

Chen, Siyi / Bennet, Laura / McGregor, Ailsa

URL

http://hdl.handle.net/2292/44257

Related subjects

Basal Ganglia / Axons / Forelimb / Animals / Mice, Transgenic / Encephalitis / Infarction, Middle Cerebral Artery / Disease Models, Animal / GAP-43 Protein / Green Fluorescent Proteins / Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Nicotinic Agonists / Drug Administration Schedule / Motor Activity / Recovery of Function / Nerve Regeneration / Time Factors / Male / alpha7 Nicotinic Acetylcholine Receptor / Varenicline

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