Efficacy of a series of alpha-pyrone derivatives against Leishmania (L.) infantum and Trypanosoma cruzi.

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Title

Efficacy of a series of alpha-pyrone derivatives against Leishmania (L.) infantum and Trypanosoma cruzi.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

The neglected tropical diseases Chagas disease and leishmaniasis affect together more than 20 million people living mainly in developing countries. The mainstay of treatment is chemotherapy, however the drugs of choice, which include benznidazole and miltefosine, are toxic and have numerous side effects. Safe and effective therapies are urgently needed. Marine alpha-pyrones have been previously identified as scaffolds with potential antiprotozoan activities. In this work, using a phenotypic s...

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Format

Research paper

Research format

Journal article

Date created

2017-10

Creator

Tempone, Andre Gustavo / Ferreira, Daiane Dias / Lima, Marta Lopes / Costa Silva, Thais Alves / Borborema, Samanta ET / Reimão, Juliana Quero / Galuppo, Mariana K / Guerra, Juliana Mariotti / Russell, Angelie J / Wynne, Graham M / Lai, Roy YL / Cadelis, Melissa / Copp, Brent

URL

http://hdl.handle.net/2292/44239

Related subjects

Leishmania infantum / Trypanosoma cruzi / Pyrones / Antiprotozoal Agents / Parasitic Sensitivity Tests / Molecular Structure / Structure-Activity Relationship / Dose-Response Relationship, Drug

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