Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model.

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Title

Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Tumour angiogenesis has long been a focus of anti-cancer therapy, however, anti-angiogenic cancer treatment strategies have had limited clinical success. Tumour-associated myeloid cells are believed to play a role in the resistance of cancer towards anti-angiogenesis therapy, but the mechanisms by which they do this are unclear. A zebrafish embryonic xenograft model has been developed to investigate the mechanisms of tumour angiogenesis and as an assay to screen anti-angiogenic compounds. In ...

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Format

Research paper

Research format

Journal article

Date created

2018-11-05

Creator

Britto, DD / Wyroba, B / Chen, Wenxuan / Lockwood, RA / Tran, Bao / Shepherd, PR / Hall, Christopher / Crosier, Kathryn / Crosier, Philip / Astin, Jonathan

URL

http://hdl.handle.net/2292/46170

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