Efficacy and safety during extended treatment of lesinurad in combination with febuxostat in patients with tophaceous gout: CRYSTAL extension study.

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Title

Efficacy and safety during extended treatment of lesinurad in combination with febuxostat in patients with tophaceous gout: CRYSTAL extension study.

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The University of Auckland Library

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ResearchSpace@Auckland

Description

BACKGROUND:In gout, long-term urate-lowering therapy (ULT) promotes dissolution of tissue urate crystal deposits. However, no studies using combined xanthine oxidase inhibition and uricosuric ULT have focused on clinical outcomes or adverse events (AEs) beyond 12 months of therapy. Our objective in the present study was to examine efficacy and long-term safety in patients with tophaceous gout receiving febuxostat plus lesinurad as combination therapy. METHODS:Patients receiving combined lesin...

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Format

Research paper

Research format

Journal article

Date created

2019-01-07

Creator

Dalbeth, Nicola / Jones, Graeme / Terkeltaub, Robert / Khanna, Dinesh / Fung, Maple / Baumgartner, Scott / Perez-Ruiz, Fernando

URL

http://hdl.handle.net/2292/46301

Related subjects

Humans / Gout / Thioglycolates / Triazoles / Gout Suppressants / Uricosuric Agents / Treatment Outcome / Drug Therapy, Combination / Adult / Middle Aged / Female / Male / Febuxostat

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