The selective rat toxicant norbormide blocks K-ATP channels in smooth muscle cells but not in insulin-secreting cells

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Title

The selective rat toxicant norbormide blocks K-ATP channels in smooth muscle cells but not in insulin-secreting cells

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Norbormide is a toxicant selective for rats to which it induces a widespread vasoconstriction. In a recent paper, we hypothesized a role of ATP-sensitive potassium (KATP) channels in norbormide-induced vasoconstriction. The current study was undertaken to verify this hypothesis by comparing the effects of norbormide with those of glibenclamide, a known KATP channel blocker. The whole-cell patch-clamp method was used to record KATP currents in myocytes freshly isolated from the rat and mouse c...

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Format

Research paper

Research format

Journal article

Date created

2019-05

Creator

Saponara, S / Fusi, F / Spiga, O / Trezza, A / Hopkins, B / Brimble, Margaret / Rennison, D / Bova, S

URL

http://hdl.handle.net/2292/48318

Related subjects

Science & Technology / Life Sciences & Biomedicine / Pharmacology & Pharmacy / norbormide / glibenclamide / K-ATP channel / patch-clamp / molecular modeling / docking / MITOCHONDRIAL PERMEABILITY TRANSITION / TAIL ARTERY MYOCYTES / POTASSIUM CHANNELS / CA2+ CHANNEL / VASOCONSTRICTOR / GLIBENCLAMIDE

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