Stationary distribution of the linkage disequilibrium coefficient r2.

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Title

Stationary distribution of the linkage disequilibrium coefficient r2.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

The linkage disequilibrium coefficient r2 is a measure of statistical dependence of the alleles possessed by an individual at different genetic loci. It is widely used in association studies to search for the locations of disease-causing genes on chromosomes. Most studies to date treat r2 as a fixed property of two loci in a finite population, and investigate the sampling distribution of estimators due to the statistical sampling of individuals from the population. Here, we instead consider t...

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Format

Research paper

Research format

Journal article

Date created

2019-08

Creator

Zhang, Wei / Liu, Jing / Goodman, Jesse / Weir, Bruce S / Fewster, Rachel

URL

http://hdl.handle.net/2292/47873

Related subjects

Models, Statistical / Genetics, Population / Linkage Disequilibrium / Alleles / Algorithms / Genetic Loci

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