Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta-cell dysfunction in type 2 diabetes

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Title

Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta-cell dysfunction in type 2 diabetes

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The University of Auckland Library

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Description

Aims/hypothesis Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with beta cell failure in type 2 diabetes and eNAMPT immuno-neutralisation improves glucose tolerance in mouse models of diabetes. Despite this, the effects of eNAMPT on functional beta cell mass are poorly elucidated, with some studies having separately reported beta cell-protec...

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Format

Research paper

Research format

Journal article

Date created

2020

Creator

Sayers, SR / Beavil, RL / Fine, NH / Huang, GC / Choudary, P / Pacholarz, KJ / Barran, PE / Butterworth, S / Mills, CE / Cruickshank, K / Silvestre, M / Poppitt, Sally / McGill, AT / Lavery, GG / Hodson, DJ / Caton, PW

URL

https://hdl.handle.net/2292/49445

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