Inhibition of the Adenosine A2A Receptor Mitigates Excitotoxic Injury in Organotypic Tissue Cultures of the Rat Cochlea.

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Title

Inhibition of the Adenosine A2A Receptor Mitigates Excitotoxic Injury in Organotypic Tissue Cultures of the Rat Cochlea.

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The University of Auckland Library

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ResearchSpace@Auckland

Description

The primary loss of cochlear glutamatergic afferent nerve synapses due to noise or ageing (cochlear neuropathy) often presents as difficulties in speech discrimination in noisy conditions (hidden hearing loss (HHL)). Currently, there is no treatment for this condition. Our previous studies in mice with genetic deletion of the adenosine A2A receptor (A2AR) have demonstrated better preservation of cochlear afferent synapses and spiral ganglion neurons after noise exposure compared to wildtype m...

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Format

Research paper

Research format

Journal article

Date created

2019-08-12

Creator

Han, Belinda Rx / Lin, Shelly Cy / Espinosa, Kristan / Thorne, Peter / Vlajkovic, Srdjan

URL

http://hdl.handle.net/2292/49880

Related subjects

Cochlea / Animals / Rats / Rats, Wistar / Hearing Loss, Noise-Induced / Purines / Tissue Culture Techniques / Models, Biological / Vestibulocochlear Nerve Injuries

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