Endoplasmic reticulum stress occurs in association with the extrusion of toxic extracellular vesicles from human placentae treated with antiphospholipid antibodies.

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Title

Endoplasmic reticulum stress occurs in association with the extrusion of toxic extracellular vesicles from human placentae treated with antiphospholipid antibodies.

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Antiphospholipid autoantibodies (aPLs), a major maternal risk factor for preeclampsia, are taken into the syncytiotrophoblast where they bind intracellular vesicles and mitochondria. Subsequently, large quantities of extracellular vesicles (EVs) extruded from syncytiotrophoblast into the maternal circulation are altered such that they cause maternal endothelial cell activation. However, the mechanism driving this change is unknown. First trimester placental explants were treated with aPL for ...

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Format

Research paper

Research format

Journal article

Date created

2020-03

Creator

Tang, Yunhui / Chen, Yan / Nursalim, Yohanes / Allan, Katie / Hickey, Anthony / Chamley, Lawrence / Chen, Qi

URL

http://hdl.handle.net/2292/50635

Related subjects

Trophoblasts / Placenta / Humans / Pre-Eclampsia / Protein Kinases / Tumor Necrosis Factor-alpha / Antibodies, Antiphospholipid / Tissue Culture Techniques / Pregnancy / Pregnancy Trimester, First / Female / HSP70 Heat-Shock Proteins / Caspase 8 / Endoplasmic Reticulum Stress / Extracellular Vesicles

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