Evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative vector for bacterial-directed enzyme-prodrug therapy

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Title

Evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative vector for bacterial-directed enzyme-prodrug therapy

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Description

© 2018 Elsevier Inc. Gene-directed enzyme-prodrug therapy (GDEPT) employs tumour-tropic vectors including viruses and bacteria to deliver a genetically-encoded prodrug-converting enzyme to the tumour environment, thereby sensitising the tumour to the prodrug. Nitroreductases, able to activate a range of promising nitroaromatic prodrugs to genotoxic metabolites, are of great interest for GDEPT. The bystander effect (cell-to-cell transfer of activated prodrug metabolites) has been quantified fo...

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Other

Date created

07 Jun, 2020

Creator

JVE Chan-Hyams / JN Copp / JB Smaill / AV Patterson / David Ackerley

URL

https://figshare.com/articles/journal_contribution/Evaluating_the_abilities_of_diverse_nitroaroma...

Related subjects

BDEPT / GDEPT / Cancer gene therapy / Nitroreductase / Bystander effect / Biomedical / Basic Science / Gene Therapy / Genetics / Infection / 5.2 Cellular and gene therapies / 2.2 Factors relating to physical environment / Aziridines / Dose-Response Relationship, Drug / Drug Evaluation, Preclinical / Escherichia coli / Genetic Therapy / Genetic Vectors / Humans / Nitroreductases / Prodrugs / Science & Technology / Life Sciences & Biomedicine / Pharmacology & Pharmacy / SUICIDE GENE-THERAPY / ESCHERICHIA-COLI / NITROREDUCTASE / BYSTANDER / CB-1954 / CANCER / NFSA / ACTIVATE / SN-23862 / HYPOXIA / Biochemistry and Cell Biology / Pharmacology and Pharmaceutical Sciences / Uncategorized

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