Ortho -Substituted lipidated Brartemicin derivative shows promising Mincle-mediated adjuvant activity

About this item

Title

Ortho -Substituted lipidated Brartemicin derivative shows promising Mincle-mediated adjuvant activity

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

This journal is © The Royal Society of Chemistry. The macrophage inducible C-type lectin (Mincle) is a pathogen recognition receptor (PRR) that is a promising target for the development of Th1-polarising vaccine adjuvants. We recently reported on the synthesis and evaluation of lipidated Brartemicin analogues that showed Mincle agonist activity, with our lead agonist exhibiting potent Th1 adjuvant activity that was greater than that of trehalose dibehenate (TDB). Herein, we report on the effi...

Read more

Format

Research paper

Research format

Scholarly text / Journal article

Date created

2020

Creator

Amy Foster / Kristel Kodar / Mattheus Timmer / Bridget Stocker

URL

https://figshare.com/articles/journal_contribution/Ortho_-Substituted_lipidated_Brartemicin_deriv...

Related subjects

Organic chemistry not elsewhere classified / Organic Chemistry / Medicinal and Biomolecular Chemistry

What is the copyright status of this item?

Share

See below for specifics about how you may use this item.

More Information

Victoria University of Wellington has this to say about the rights status of this item:

CC BY-NC-ND 4.0

What can I do with this item?

You must always check with Victoria University of Wellington to confirm the specific terms of use, but this is our understanding:

Non-infringing use

NZ Copyright law does not prevent every use of a copyright work. You should consider what you can and cannot do with a copyright work.

Share it

This item is suitable for copying and sharing with others, without further permission.

No modifying

You are not allowed to adapt or remix this item into any other works.

No commercial use

You may not use this item commercially.