Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis.

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Title

Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

BACKGROUND:More effective and safer treatments are needed for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. METHODS:We conducted a randomized trial with a 2-by-2 factorial design to evaluate the use of plasma exchange and two regimens of oral glucocorticoids in patients with severe ANCA-associated vasculitis (defined by an estimated glomerular filtration rate of <50 ml per minute per 1.73 m2 of body-surface area or diffuse pulmonary hemorrhage). Patients were randomly assi...

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Format

Research paper

Research format

Journal article

Date created

2020-02

Creator

Walsh, Michael / Merkel, Peter A / Peh, Chen-Au / Szpirt, Wladimir M / Puéchal, Xavier / Fujimoto, Shouichi / Hawley, Carmel M / Khalidi, Nader / Floßmann, Oliver / Wald, Ron / Girard, Louis P / Levin, Adeera / Gregorini, Gina / Harper, Lorraine / Clark, William F / Pagnoux, Christian / Specks, Ulrich / Smyth, Lucy / Tesar, Vladimir / Ito-Ihara, Toshiko / de Zoysa, Janak / Szczeklik, Wojciech / Flores-Suárez, Luis Felipe / Carette, Simon / Guillevin, Loïc / Pusey, Charles D / Casian, Alina L / Brezina, Biljana / Mazzetti, Andrea / McAlear, Carol A / Broadhurst, Elizabeth / Reidlinger, Donna / Mehta, Samir / Ives, Natalie / Jayne, David RW / PEXIVAS Investigators

URL

http://hdl.handle.net/2292/51830

Related subjects

PEXIVAS Investigators / Humans / Kidney Diseases / Kidney Failure, Chronic / Cyclophosphamide / Immunosuppressive Agents / Glucocorticoids / Plasma Exchange / Combined Modality Therapy / Administration, Oral / Incidence / Dose-Response Relationship, Drug / Adult / Aged / Middle Aged / Female / Male / Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Induction Chemotherapy / Rituximab

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